کلینک سرطان پردیس

انستیتو کانسر پردیس

سلامت نیاز نخست

دکتر اکبر صفائی

دکتر اکبر صفائی
دکتر اکبر صفائی

دکتر اکبر صفائی

متخصص پاتوبیولوژی

Curriculum vitae 

Name: Akbar Safaei,


Department of Pathology

Shiraz University of Medical Sciences,



PO Box: 71345-1864 Telephone: 00987132301784




2015-present: Professor of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran

2015- present :Head  of Department of Pathology

2014-present: Member of Breast cancer  Research Center


2013 – present :Fellowship of molecular pathology and cytogenetic

2010-2015: Associated Professor of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran

2007-present: Director of Cytogenetic  Laboratory, Shiraz University of Medical Sciences, Shiraz, Iran

2006-2010: Director of the Pathology and Laboratory Medicine Dept., Faghihi hospital, Shiraz, Iran

2005-2010: Assistant Professor of Pathology, Shiraz University of Medical Sciences

2002-2005: Director of the Pathology Laboratory Medicine Dept, Shaheed Rajaee Cardiovascular Research Center, Tehran, Iran

2001-2005: Assistant Professor of Pathology, Shaheed Rajaee

Cardiovascular Research center, Tehran, Iran


2011-2013: fellowship of molecular pathology and cytogenetic


1987-2001:  Pathology (AP/CP): Shiraz University of Medical Sciences,

Shiraz, Iran Board Certified in Pathology (AP/CP)

1977-1984: Diploma of Medicine: Tehran University of Medical Sciences, Iran



1-Safaei A, Saluti R, Kumar PV.Conjunctival dysplasia in soldiers exposed to mustard gas during the Iraq-Iran war: scrape cytology.Acta Cytol. 2001; 45(6):909-13. 


2-Kumar PV, Ashraf MJ, Safaei A, Ali Ghayoomi S, Moosavi H, Davari HR.Fine needle aspiration diagnosis of bronchogenic cysts.Acta Cytol. 2001; 45(4): 656-8. 

3-Kumar PV, Moosavi A, Karimi M, Safaei A, Noorani H, Abdollahi B, Bedayat GR. Subclassification of localized Leishmania lymphadenitis in fine needle aspiration smears.Acta Cytol. 2001; 45(4):547-54

4-Fotouhi A.  ,Asghari F.  , Mirazazadeh A. , Alaaldini F. , Yazdani K. , Aria A., Safaei A, Vafadar J.. Comparison of therapeutic and short term side effect of Anethum with nicotinic acid,cholestyramin,the combination of the two and placebo for isolated hypercholesterolemia; a double blind randomized clinical trial.Journal of Medical Plants,Summer 2002;1(3)


5-Safaei A, Motazedian MH, Vasei M.Polymerase chain reaction for diagnosis of cutaneous leishmaniasis in histologically positive, suspicious

and negative skin biopsies.Dermatology. 2002;205(1):18-24

6-Maleki M, Safaei A, Roshanali F, Moshkani Farahani m.Incidental mesothelial / monocytic cardiac excrescence and literature review. IHj, 2003 ; 3(2&3) :61-65

7- Sadeghpour A , Maleki M , Noohi F , Ojaghi S Z , Esmaielzadeh M , Safaei A , Hosseini S Broncogenic cyst presenting as a large unilocular left atrium mass. IHj,2003 ; 3(4) :74-76

8-Akbarzadeh Z, Esmailzadeh M, Yousefi A, Safaei A, Raisi K, Sharifi F. Multicentric familial cardiac myxoma.Eur J Echocardiogr. 2005; 6(2): 148-5 

9- Esmaeilzadeh M, Tavakolli A, Safaei A. Recurrent intracardiac leiomyomatosis.: Can J Cardiol. 2007; 23(13):1085-6.


10-Tabei SZ,Safaei A.  HTLV1 infection in the world and

Khorasan.Review Article. Birjand Med J.2008; 15: 5-16

11- Tabei SH,Safaei A, Tabei SZ.Evaluation of clinical pathology knowledge in the clinical residents of medical sciences. J M Council IRI.2008 26,(2):258-30

12-Hosseini H,Safaei A,Hkalili MR, Nowrozizadeh B,Eghtedari M,Farvardin M , Nowrozizadeh S, Tolideie HR. Intravitreal infliximab in experimental endotoxin-induced uveitis. Eur J Ophthalmol 2009; 19: 818823

  1. Seyed Ziaeddin Tabei , Fatemeh Asadian ,Mahdi Fakhar , Akbar Safaei. Gastrointestinal hyper infection due to Strongyloides stercoralis in a patient with Behcets syndrome. Comp Clin Pathol (2009) 18:89–91


14- Akbar Safaei, Mahsa Khanlari, Moghdeh Momtahen, Ahmad

Monabati,Minoo Robati, Sedigheh Amooei, Behnaz  Valibeigi, Negar Azarpira. Prevalence of high-risk human papillomavirus types 16 and 18 in healthy women with cytologically negative Pap smear in Iran. The Indian Journal of Pathology and Microbiology . 2010 Oct-Dec;53(4):6815.


15- Akbar Safaei, Mohammad Vasei, Hossein Ayatollahi,Cytogenetic Analysis of Patients with Primary Amenorrhea in Southwest of Iran.

Iranian Journal of Pathology (2010);  5(3):121-125

16-Razmkhah M, Jaberipour M, Hosseini A, Safaei A, Khalatbari B, Ghaderi A. Expression profile of IL-8 and growth factors in breast cancer cells and adipose-derived stem cells (ASCs) isolated from breast carcinoma. Cell Immunol. 2010;265(1):80-5. 

17- Mohammad Bagher Sharifkazemi1, Akbar Safai2, Amir Aslani1*,

Seifollah Dehghan3, Ali Rezakhani3, Gholam Reza Rezaian1Effect of

Electrical Cardioversion on Stented Coronary Artery. Cent. Eur. J. Med. • 5(3) • 2010 • 303-307


18-Zomorodian K, Rahimi MJ, Safaei A, Bazargani A, Motamadi M, Kharazi M, Mostaghni S, Pakshir K, Ghaedi H, Afsarian MH. Analysis of beta-hemolysis in human blood agars by Streptococcus pyogenes.J Microbiol Methods.In Press, Corrected Proof, Available online 25 March 2011

  1. Mozhdeh Momtahan,1 Maryam Nemati,1 and Akbar Safaei2 Disseminated Peritoneal Leiomyomatosis Iran J Med Sci. Mar 2011; 36(1): 57–59.


  1. Zahra Mojtahedi, Akbar Safaei, Zahra Yousefi, Abbas Ghaderi. Immunoproteomics of HER2-Positive and HER2-Negative Breast Cancer Patients with Positive Lymph Nodes. OMICS. 2011 Jun;15(6):409-18. 

21-Safaei A, Khanlari M, Azarpira N, Monabati A. Large ovarian leiomyoma in a postmenopausal woman.Indian J Pathol Microbiol. 2011 Apr-Jun;54(2):413-4

22-- Safaei A, Vasei M, Attaranzadeh A, Azad F, Tabibi N.

Chromosomal abnormality in patients with secondary amenorrhea.Arch Iran Med. 2012 Apr;15(4):232-4.

23- Seghatoleslam A, Nikseresht M, Shafiee SM, Monabati A, Namavari

MM, Talei A, Safaei A, Owji AA Expression of the novel human gene,

UBE2Q1, in breast tumors. Mol Biol Rep. 2012 May;39(5):5135-41

  1. Safaei A, Razeghi A, Monabati A, Azarpira N, Talei A .Comparing touch imprint cytology, frozen section analysis, and cytokeratin immunostaining for intraoperative evaluation of axillary sentinel lymph nodes in breast cancer.Indian J Pathol Microbiol. 2012 Apr;55(2):183-6.

25- Safaei A, Farzaneh MR, Amin Sharifi AR. Immunohistochemistery

Study in a Case of Nephrogenic Adenoma of Bladder

 IJMS Vol 37, No 2, June 2012


26- Mahboobeh Razmkhah1, Mansoureh Jaberipour1, Akbar Safaei

Abdol-Rasoul Talei3,Nasrollah Erfani1, Abbass Ghaderi1,4 Chemokine and chemokine receptors: a comparative study between metastatic and nonmetastatic lymph nodes in breast

cancer patients. Eur. Cytokine Netw. Vol. 23 n◦ 3, July-AugustSeptember 2012, 72-7


27-Hodjati H, Salehipour M, Safai A, Boveiri K, Hekmati P, Hadian P, Tanideh N. Use of Autologous Renal Capsule Grafts for Venous Repair Urology. 2013 Jan 9. 


.28- Sari Aslani F, Safaei A, Pourjabali M, Momtahan M.

Evaluation of Ki67, p16 and CK17 Markers in Differentiating Cervical Intraepithelial Neoplasia and Benign Lesions.

Iran J Med Sci. 2013 Mar;38(1):15-21.


29- Shafiee SM, Seghatoleslam A, Nikseresht M, Hosseini SV, AlizadehNaeeni M, Safaei A, Owji AA.UBE2Q1 expression in human colorectal tumors and cell lines.

Mol Biol Rep. 2013 Dec;40(12):7045-51. doi: 10.1007/s11033-013-28248. Epub 2013 Nov 7.


30- Safaei A, Shahryari J, Farzaneh MR, Tabibi N, Hosseini

M.Cytogenetic Findings of Patients with Acute Lymphoblastic Leukemia in Fars Province.  

Iran J Med Sci. 2013 Dec;38(4):301-307.


31- Faghih Z, Erfani N, Haghshenas MR, Safaei A, Talei AR, Ghaderi A Immune profiles of CD4+ lymphocyte subsets in breast cancer tumor draining lymph nodes..

Immunol Lett. 2013 Dec 7. doi:pii: S0165-2478(13)00205-8


32- Sedigheh Tahmasebi, Behnam Dalfardi, Abdolrasoul Talei, Akbar

Safaei, Ahmad Monabati, Majid Akrami Concordant Expression of

Estrogen and Progesterone Receptors in Primary and Loco-regional

Recurrent Breast Cancer Middle East Journal of Cancer 2013; 4(3): 113118


33- Jafarian, A., Hajizadeh, M. R., Safaei, A., Miri, R., Sardarian, A.-R., Mostafavi-Pour, Z. Effect of walnut male flower extract on islet regeneration and glukokinase activity, Diabetes stoffw herz ,2013;22,283287


  1. Akbar Safaei, Mohamad Reza Farzaneh, Sadat Noori

Cytogenetic Analysis of Referral Cases with Growth Failure and Clinical

Suspicion of having Chromosomal Abnormality, Iranian Journal of

Pathology (2013) 8 (2), 104 – 109


35- Akrami M, Talei A, Nazemzadegan B, Abdollahi A, Aslani FS, Safaei A, Tahmasebi S.Low grade malignant proliferating pilar tumor arising from breast skin simulating squamous cell carcinoma, a case report. Indian J Surg Oncol. 2013 Dec;4(4):397-8. doi: 10.1007/s13193013-0275-2. Epub 2013 Nov 13. 


36- Ziaian B, Saberi A, Ghayyoumi MA, Safaei A, Ghaderi A, Mojtahedi Z.Association of High LDH and Low Glucose Levels in Pleural Space with HER2 Expression in Non-Small Cell Lung Cancer.

Asian Pac J Cancer Prev. 2014;15(4):1617-20.


37- Akbar Safaei1, Seyed Masood Tabib2, Mohamad Reza Farzaneh1,  

Jahanbanoo Shahryari1, Mohamad Bahmaniar3 . Primary Malignant

Melanoma of the Gastrointestinal Tract: Report of Two Cases.  Iranian

Journal of Pathology (2014) 9 (3), 215 – 220


38- Leila Pirmoradi1, Mohammad Taghi Mohammadi1, Akbar Safaei2,

Fakhardin Mesbah3 and Gholam Abbas Dehghani*Does the Relief of

Glucose Toxicity Act As a Mediator in Proliferative Actions of

Vanadium on Pancreatic Islet Beta Cells in Streptozocin Diabetic Rats? Iranian Biomedical Journal 18 (3): 173-180 (July 2014)


39- Negar Azarpıra, Puria Noshadı, Sara Pakbaz, Simin Torabıneghad,

Mohamad Rakeı,Akbar Safaı2 Dural Plasmacytoma Mimicking Meningioma. Turk Neurosurg 2014, Vol: 24, No: 3, 403-405


  1. Safaei A, Shokripour M, Omidifar N.-Bone marrow and karyotype findings of patients with pancytopenia in southern iran.Iran J Med Sci. 2014 Jul;39(4):333-40
  2. Safaei A, Bagheri M, Shahryari J, Noori S, Esmailzade E.Langerhans cell histiocytosis followed by hodgkin lymphoma: a case report.Iran J Med Sci. 2015 May;40(3):282-6.
  3. Monabati A, Sokouti AR, Noori SN, Safaei A, Talei AR, Omidvari S, Azarpira N.Large palpable ductal carcinoma in situ is Her-2 positive with high nuclear grade.Int J Clin Exp Pathol. 2015 Apr 1;8(4):3963-70

43-Farzaneh Mohamad Reza,Shahryari Jahanbanoo,Safaei akbar,Valibeigi Behnaz,Karimi davani shahrbanoo,Tabibi

Narjes.Downregulation of dicer gene expression is associated with The risk of acute myelogenous leukemia and chronic lymphocytic leukemia,In a sample of fars province,Iran.IJMS (Accepted) 

  1. Mahmoudvand S, Safaei A, Erfani N, Sarvari J. Presence of Human Papillomavirus DNA in Colorectal Cancer Tissues in Shiraz, Southwest Iran.Asian Pac J Cancer Prev. 2015;16(17):7883-7
  2. Mehdipour F, Razmkhah M, Hosseini A, Bagheri M, Safaei A, Talei AR, Ghaderi A.i ncreased B regulatory phenotype in non-metastatic lymph nodes of node positive breast cancer patients.Scand J Immunol. 2015 Dec 27. doi: 10.1111/sji.12407. [Epub ahead of print]
  3. Tahoora Shomali, Alireza Rafati, Mehdi Fazeli,Akbar Safaei. Mohammad Kamalpour.Localization, Cellular Density and Gene Expression of HCA2 Receptors in Femoral Epiphysis and Metaphysis of Normal and Niacin-Treated Rats. Biomedical & Pharmacology Journal

Vol. 8(2), 667-674 (2015) 

  1. Monabati A, Safaei A, Noori S, Mokhtari M, Vahedi A.Subtype distribution of lymphomas in South of Iran, analysis of 1085 cases based on World Health Organization classification. Ann Hematol. 2016 Mar;95(4):613-8. doi: 10.1007/s00277-016-2590-5. Epub 2016 Jan 12. 48- Monabati A, Vahedi A, Safaei A, Noori S, Mokhtari M, Vahedi L,

Zamani M. Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma: Is It Different between Over and Under 50 Years of Age? Asian Pac J Cancer Prev. 2016;17(4):2285-9

49- Farzaneh MR, Shahryari J, Safaei A, Valibeigi B, Davani SK, Tabibi

N.Dicer Gene Expression as a Prognostic Factor in Acute Lymphoblastic Leukemia and Chronic Lymphocytic Leukemia in Fars Province.Iran J Med Sci. 2016 May;41(3):223-9.


  1. Safaei A, Saluti R, Kumar PV Conjunctival dysplasia in soldiers exposed to mustard gas during the Iraq-Iran war: scrape cytology. Annual Pathology Conference,Tehran, Iran 2002  
  2. Safaei A, Motazedian MH, Vasei M Polymerase chain reaction for diagnosis of cutaneous leishmaniasis in histologically positive, suspicious and negative skin biopsies. Annual Pathology Conference Tehran, Iran 2002 

3-Safaei A,Vasei M, Azad F, Tabibi N.Cytogenetic finding in primary amenorrhea. Annual Pathology Conference ,Tehran, Iran 2007  

  1. Safaei A, Tabei SZ .Tabei SH. Evaluation of clinical pathology knowledge in the clinical residents of medical sciences, Kerman Medical Education Congress, Kerman, Iran 2007
  2. Hossinzadeh M, Safaei A, Ashraf M.Cytological findings of helicobacter pylori related gastic mucosa abnormalities in touch imprint smears.  Society for general Microbiology, 160 th meeting , University of Manchester, 2007
  3. Safaei AVasei M, Tabibi N 7- Safaei A,Vasei M, Azad F, Cytogenetic finding in azoospermic patients . Annual Pathology Conference,Tehran, Iran 2008  

8- Kumar PV, Safaei A, Palizian A.Aslani F , Monabati A.The role of PCR and IHC in differenciation of cervix dysplasia from benign lesions. World congress of cervical pathology and colposcopy 2008

9-46, XX male sex reversal syndrome: a case report. Annual Pathology Conference,Tehran, Iran 2009

  1. A case of klinefelter syndrome with 48, XXYY. Annual Pathology Conference ,Tehran, Iran 2009
  2. ER, PR and HER2/neu markers in breast carcinoma: comparison of

immunocytochemistry and immunohistochemistry. Annual Pathology Conference ,Tehran, Iran 2009

  1. Prevalence of cervical Human papillomavirus infection in the women seeking cervical Papanicolaou cytology in the south of Iran. Annual Pathology Conference ,Tehran, Iran 2009
  2. Safaei A, Azad F. Detection of a novel chromosomal translocation in a woman with recurrent abortions.. Annual Pathology Conference,Tehran, Iran 2010
  3. Safaei A, Hosseini M. Klinfelter syndrome with a rare reciprocal translocation        t(3;12).. Annual Pathology Conference ,Tehran, Iran 2010
  4. Safaei A, Attaranzadeh A, Tabibi N... Annual Pathology Conference,Tehran, Iran 2010 
  5. Safaei A, Attaranzadeh A, Vasei M  Cytogenetic study in patients with secondary

 amenorrhea in southwest of Iran The 8th European Cytogenetics Conference,Porto,Portugal,2011

  1. Safaei A .Detection of rare chromosomal translocations in couple with recurrent abortions. The 13th annual pathology Conference,Tehran ,Iran
  2. I Safaei A. Immunohistochemistry Study in a Case of Nephrogenic Adenoma Arising from urinary bladder.  The 13th annual pathology Conference,Tehran ,Iran                                                                                                       
  3. Safaei A. Detection of a novel chromosomal translocation in an azospermi patient. The 13th annual pathology Conference,Tehran ,Iran
  4. Safaei A. High lights of cytogenetic findings in hematological malignancies. The 16th annual pathology Conference,Tehran ,Iran



1-Molecular pathology and cytogenetic

  1. Hemathopathology
  2. Breast pathology

5- Blood bank



First Rank in the Board Examination of Pathology awarded by Ministry of Health 2001


صبح ساعت  8 الی 12   عصر ساعت 18 الی 21



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